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Fighting Sudden Cardiac Death: A Worldwide Challenge (book)

Edited by Etienne Aliot, MD, FESC, FACC, Chief, Department of Cardiology, Hospital Central, University of Nancy, France
Jacques Clementy, MD, FESC, Chief, Department of Cardiology, Hospital du Haut-Levêque, University of Bordeaux, France
Eric N. Prystowsky, MD, Director, Clinical Electrophysiology Laboratory, St. Vincent Hospital, Indianapolis, IN; Consulting Professor of Medicine, Duke University Medical Center, Durham, NC

750 pp. (approx.), 150 illus., 35 tables, 6x9 hardcover, 0-87993-460-3 September 2000......$125.00 (Approximate)

Fighting Sudden Cardiac Death: A Worldwide Challenge reviews the background of sudden cardiac death (SCD) in light of new advances in genetics, mechanisms of therapy, and prevention, thus providing the reader with a more unified view of SCD, a better understanding of the pathological mechanisms of SCD, and the tools needed to identify the appropriate treatment for patients at risk for a primary event. 

Its 50 chapters incorporate expert findings on a wide variety of relevant subjects, ranging from cell to examination, from idiopathic arrhythmias and SCD in athletes to arrhythmogenic heart failure, from long QT syndrome to ventricular dysplasia, from prehospital resuscitation to very sophisticated implantable devices. In-depth discussions on the background, therapy and prevention of SCD serve to increase and improve the tools available to battle this "serial killer."


Cardiologists, electrophysiologists, and internists, both in clinical practice and in the laboratory, will find a great deal of valuable information in this book.


I: Definition, Epidemiology, and Mechanisms
Definitions and Epidemiology of Sudden Cardiac Death   Robert J. Myerburg, Raul M. Mitrani, Alberto Iterian, Jr., Martin Kloosterman, Jeffrey Simmons, and Agustin Castellanos

The Classification of Sudden Death in Clinical Trials Luc J.L.M. Jordaens
How Genetics May Help to Understand and Prevent Sudden Cardiac Death: Ketty Schwartz

Autonomic Nervous System and Sudden Cardiac Death Hugh Calkins

Apoptosis and Sudden Cardiac Death  Ziad Mallat, Bénédicte Hugel, Guy Lesèche, Jean-Marie Freyssinet, and Alain Tedgui

Spatiotemporal Organization of Ventricular Fibrillation Increases during Global Ischemia in the Isolated Rabbit Heart  Jay Chen, Ravi Mandapati, Omer Berenfeld, Moussa Mansour, and José Jalife

The Role of Early Afterdepolarizations in Lethal Ventricular Arrhythmias Ralph Lazzara and Bela Szabo

Regional Differences in Electrophysiology of Ventricular Cells: Clinical Implications for Sudden Cardiac Death
Charles Antzelevitch

Nonfibrillatory Sudden Cardiac Death: Role of Bradycardia: Jean-Jacques Blanc and Jacques Mansourati

Sudden Cardiac Death: The Pathology Perspective Michael Davies

II: Out of Hospital Sudden Cardiac Death
Automated External Defibrillation in Europe Leo Bossaert

The Maastricht Study: A Plea for New Approaches to Improve Results of Out-of-Hospital Resuscitation Hein J.J. Wellens, Jacqueline de Vreede-Swagemakers, Aimée Lousberg, and Anton M. Gorgels

European Resuscitation Council Guidelines for Resuscitation of the Adult Cardiac Arrest Victim Leo Bossaert

Evidence-Based Guidelines in Resuscitation: From Experiment to Guidelines Lance B. Becker

III: Normal Heart, Sports, and Sudden Cardiac Death
Sudden Cardiac Death in Young Athletes: Epidemiology, Screening, and Prevention Barry J. Maron

Idiopathic Ventricular Fibrillation Silvia G. Priori and Lia Crotti

IV: Arrhythmogenic Right Ventricular Dysplasia
Why Patients with Arrhythmogenic Right Ventricular Dysplasia Die Suddenly G. Fontaine, P. Fornes, Z. Mallat, F. Fontaliran, and R. Frank

Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Genetic or an Acquired Disease?  Domenico Corrado, Cristina Basso, Marialuisa Valente, and Gaetano Thiene

Therapies for Prevention of Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy   Thomas Wichter, Martin Borggrefe, Dirk Böcker, and Günter Breithardt

V: Sudden Cardiac Death and Repolarization
The Long QT Syndrome: From Genotype to Phenotype  Peter J. Schwartz

Congenital Long QT Syndrome: Therapeutic Considerations Based on the International LQTS Registry  Arthur J. Moss and Wojciech Zareba

Brugada Syndrome: From Genetics to Clinical Management  Pedro Brugada, Josep Brugada, Ramon Brugada, Jeffrey Towbin, and Charles Antzelevitch

VI: Heart Failure
Are There Specific Risk Markers of Sudden Cardiac Death in Heart Failure Patients?  J.Y. Le Heuzey, X. Copie, O. Piot, T. Lavergne, D. Digeos-Hasnier, and L. Guize

Sudden Cardiac Death in Idiopathic Dilated Cardiomyopathy  Pierre Cosnay, Laurent Fauchier, Dominique Babuty, Danielle Casset-Senon, David Tena-Carbi, Jean-Christophe Charniot, Philippe Poret, and Jean-Paul Fauchier

Mechanisms of Sudden Death in Hypertrophic Cardiomyopathy: Implications for Risk Stratification  Paul Sorajja, Perry M. Elliott, and William J. McKenna

Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathies Riccardo Cappato

The Implantable Cardioverter-Defibrillator as a Bridge to Transplantation: Is it Worthwhile? Antonio Raviele

VII: Pediatrics
Neuromuscular Disorders and Sudden Death  Denis Duboc, Jean Varin, Henry Marc Becane, Gisele Bonne, Zine Ounnoughenne, and Arnaud Lazarus

Sudden Cardiac Death After Surgery of Congenital Cardiac Diseases E. Villain

VIII: Etiologies
Sudden Death in Mitral Valve Prolapse  Jean-Paul Fauchier, Dominique Babuty, Laurent Fauchier, Christian Marchal, Danielle Casset-Senon, Pierre Cosnay, and Christian Neel

Sudden Death in Patients with Cardiac Conduction Disorders Henri E. Kulbertus

Myocarditis: An Underestimated Cause of Sudden Cardiac Death Cristina Basso, Fiorella Calabrese, Domenico Corrado, and Gaetano Thiene

IX: Ischemia and Sudden Cardiac Death
Arrhythmias in Acute Ischemia Michiel J. Janse
Mechanisms of Ventricular Arrhythmias in the Subacute and Late Post-Infarction Period Nabil El-Sherif, Boyu Huang, and Dmitry O. Kozhevnikov

X: Markers of Sudden Cardiac Death in the Era of Revascularization

Usefulness of Premature Ventricular Contractions and Late Potentials for Risk Stratification after Myocardial Infarction in the Era of Revascularization  Salem Kacet and Claude Kouakam

Baroreflex Sensitivity and Heart Rate Variability: State of the Art and Perspective  Marek Malik and Irina Savelieva

Markers of Sudden Cardiac Death. Clinical Usefulness of the QT Study: QT Duration, QT Dispersion, QT Dynamicity, and T-Wave Alternans  Antoine Leenhardt, Pierre Maison Blanche, Fabrice Extramiana, Paul Milliez, and Philippe Coumel

Value of Programmed Ventricular Stimulation to Select Candidates at Risk for Sudden Cardiac Death  Eric N. Prystowsky

Value of Left Ventricular Function Stratification  Karl Isaaz
Nonsustained Ventricular Tachycardia: Prognostic and Therapeutic Considerations  Nadir Saoudi, Frederic Anselme, Maxime Chalumeau, Arnaud Savoure, and Alain Cribie

XI: Prevention
The Role of Stress in Sudden Death: Can it be Prevented? Philippe Coumel

Can Diet Prevent Sudden Cardiac Death? Michel de Lorgeril

XII: Medical Therapy
Mechanisms of Defibrillation Nipon Chattipakorn and Raymond E. Ideker

Can Nonarrhythmic Drugs Prevent Sudden Cardiac Death? Aliot, C. de Chillou, I. Magnin-Poull, and N. Sadoul

XIII: Nonmedical Therapy
Ventricular Tachycardia Antiarrhythmic Surgery: The Legacy Gerard M. Guiraudon, George J. Klein, and Colette M. Guiraudon

XIV: Automatic Implantable Cardioverter-Defibrillators
A Critical Appraisal of Implantable Cardioverter-Defibrillator/Drug Trials in the Secondary Prevention of Sudden Cardiac Death
Gerald V. Naccarelli, Deborah L. Wolbrette, Hemantkumar T. Patel, and Jerry C. Luck

Quality of Life in Patients with Implantable Cardioverter-Defibrillators  Christian Wolpert, Werner Jung, Susanne Herwig, and Berndt Lüderitz

Economic Aspects of Implantable Cardioverter-Defibrillator Therapy Owen A. Obel and A. John Camm

Can We Learn From Ongoing Implantable Cardioverter-Defibrillator Trials? Martin Fromer

The Future: A Hybrid Therapy Sanjeev Saksena